Red Imported Fire Ants are not considered to be a vector of any disease, however their stings are of an important public health concern. Home invasions can threaten small children, the elderly, and pets.

Stings may produce a range of reactions from localized pain and swelling to anaphylactic shock.

RIFA respond rapidly and aggressively to any disturbance of the colony. A single fire ant can sting repeatedly and will continue to do so even after their venom sac has been depleted. Initially, the stings result in a localized intense burning sensation followed by the formation of a white pustule at the sting site within 24 - 48 hours.